I just tested a brand new EZIO2X4 with the latest version firmware on the ISY (4.1.2) and was able to see status changes, so we know there is nothing wrong with compatibility in general.
Now, to understand what’s going on with your device…are you able to link an input to control any other INSTEON controller, like a light switch or lamp module?
Have you made sure to ground your analog inputs if you’re not using them, in case there might be so much traffic on the powerline right now that you’re not able to see the status changes.
Also, what do you have connected to the inputs and how are they connected?
That will help us determine if we’re able to get signal sent out from the EZIO2X4.