There is no X10 message associated with an Input changing state.
Define an Insteon device and link Input 1 and Input 2 to the powerline controller used by Homeseer. If done with the Set button process the EZIO2X4 Input is a Controller and the powerline controller is a Responder. When done with the Set button the EZIO2X4 configuration is done automatically. Input 1 state change generates a Group 1 On/Off. Input 2 state change generates a Group 2 On/Off.
I’m not familiar with Homeseer. It may have a method to do the linking and EZIO2X4 configuration.